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Print Advertisement In research that could give doctors a way to reassign sex in cases of unclear gender, scientists report this week that they have figured out why some children with genes that should make them boys are instead born as girls. The study, published in Nature , explains why some embryos with X and Y chromosomes—which should be born as male—develop ovaries and eventually become girls. The key is whether a gene called Sox9, involved in formation of the testes, is active. This is all speculation but it's possible. To work out this process, Lovell-Badge and his colleagues manipulated the Sox9 gene in genetically engineered mice. They found that what switches on Sox9 is the product of two other genes.
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